New centre in Singapore will study impact of gut bacteria on diseases like dementia & More News Here

SINGAPORE – To study how the bacteria residing in our gut have an effect on well being and ageing, and the way they may very well be harnessed to delay the onset of age-related neurodegenerative diseases comparable to dementia, a brand new centre was launched right here on Friday (June 3).

The Asean Microbiome and Nutrition Centre is a digital centre primarily based on the National Neuroscience Institute (NNI) – a partnership between NNI and Sunway University in Malaysia – that will deliver experimental microbiome analysis from the lab right into a medical setting.

The ecosystem of bacteria, fungi and different microbes discovered in the digestive system is collectively known as the gut microbiome. These microbes secrete chemical compounds known as metabolites, that are absorbed into the bloodstream.

These metabolites then journey to completely different elements of the physique such because the mind, liver and bone, the place they may very well be both useful or dangerous to the tissue, relying on the sort of metabolite and the placement it travelled to.

The gut microbiome is subsequently important for human well being and well-being because it performs an element in regulating immunity, metabolism, behaviour and organ operate in varied elements of the physique.

Professor Sven Pettersson, the director of the centre and a principal investigator at NNI’s Department of Research, stated that finding out how gut microbes talk with tissues, such because the mind, can pave the way in which for brand spanking new therapies to stop and handle age- and lifestyle-related diseases.

“In contrast to our genes, which are not easy to change, our gut microbes are malleable and respond to diet. That makes them very attractive to be targeted by food intervention,” he added.

For occasion, a high-fibre, low-processed food regimen wealthy in fruits, greens, nuts and seeds, helps useful bacteria flourish in the gut, stated Prof Pettersson.

The centre can also be working intently with the native meals trade to develop next-generation meals merchandise to assist gut microbes higher assist human well being and the ageing physique.

Professor Louis Tan, who’s senior guide neurologist and director at NNI’s Department of Research, stated that the primary analysis linking the gut microbiome to the mind was revealed lower than 20 years in the past.

It was discovered that microbes may both be useful or detrimental, relying on one’s food regimen and existence, that are the “master regulators” of human well being, he added.

For occasion, the microbes may secrete metabolites that cut back irritation and enhance reminiscence or metabolites that speed up irritation and age-related illness signs in the physique.

“There is still much we do not know. NNI is glad to collaborate with researchers from around the world to advance knowledge and care for our patients,” stated Prof Tan.

The centre can also be participating researchers in Europe, North America and Asia to determine how microbial mechanisms regulate ageing. It is supported by the UK Dementia Research Institute and was arrange with funding from the Jeffrey Cheah Foundation.

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